Is FP dying? H-- NO!

IN BEHALF OF FAMILY PRACTICE

We have discussed the fact that experiments have shown that the cytokine cycle and MMPs (matrix metaloproteinases) are involved with a myriad of life process pathology such as cell division to metastatic cancer, normal fast conduction nerve fiber with Nodes of Ranvier to myelin sheath loss and dysfunctional nerve conduction seen in MS, and normal renal function to post impetigo glomerulonephritis with renal dysfunction. The normal blood elements/function to clotting seen in myocardial infarctions (acute cardiac syndrome) and strokes also involve a normal MMP and cytokine cycle seen in the nascent immunologic state to ones that have gone awry . This is seen in strokes and heart attacks and other clotting states. A dysfunctional cytokine cycle seen with the inflammatory cytokines IL1, TNF-alpha an IL6 constitute a 3 man team that if unchecked by itself can lead to clotting disorders.

Yet the normal MMP function (specifically remodeling) could be involved in pathologic processes when the process of remodeling goes unchecked. These processes include MS which is a type of “dysfunctional modeling” involved in autoimmune processes. Today we will explore the question. Can you have a normal cytokine cycle and a purely dysfunctional MMP ? I believe the answer is no. This therefore allows for the possibility of cytokine abnormalities as tumor, MI, stroke and autoimmune disorders’
MARKERS with MMP abnormalities being late markers of disease .

This brings up investment opportunities in cytokine measurement and the possibility that the trained the Family Practitioner will again be the best observer in love for these diseases prior to their needing hospitalization and emergency room visits.